Modes of resistance to anti-angiogenic therapy
نویسندگان
چکیده
منابع مشابه
Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
Despite the approval of several anti-angiogenic therapies, clinical results remain unsatisfactory, and transient benefits are followed by rapid tumor recurrence. Here, we demonstrate potent anti-angiogenic efficacy of the multi-kinase inhibitors nintedanib and sunitinib in a mouse model of breast cancer. However, after an initial regression, tumors resume growth in the absence of active tumor a...
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most types of cancers, and particularly in metastatic renal cell carcinoma, with several drugs currently approved for daily clinical practice. However, secondary resistance to this family of drugs is constantly observed, and the mechanisms of resistance remain poorly understood in patients. Recently, we demonstrated that sunitinib, a tyrosine kinase inhibitor, was able to generate resistance to...
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An adequate blood supply is essential for cancer cells to survive and grow; thus, the concept of inhibiting tumor angiogenesis has been applied to cancer therapy, and several drugs are already in clinical use. It has been shown that treatment with those anti-angiogenic drugs improved the response rate and prolonged the survival of patients with various types of cancer; however, it is also true ...
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Pancreatic cancer remains one of the most lethal and poorly understood human malignancies and will continue to be a major unsolved health problem in the 21(st) century. Despite efforts over the past three decades to improve diagnosis and treatment, the prognosis for patients with pancreatic cancer is extremely poor with or without treatment, and incidence rates are virtually identical to mortal...
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Anti-angiogenic therapy has been demonstrated to increase progression-free survival in patients with many different solid cancers. Unfortunately, the benefit in overall survival is modest and the rapid emergence of drug resistance is a significant clinical problem. Over the last decade, several mechanisms have been identified to decipher the emergence of resistance. There is a multitude of chan...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2008
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2442